This innovating test is an indirect marker of Tissue Factor exposure In Vivo.
Tissue Factor (TF), a potent initiator of the blood clotting time system, is an integral membrane protein present on the surface of certain cell types located outside the vasculature and on circulating microparticles.
A primary step in the coagulation cascade is the formation of [VIIa-TF] complex that activates both factor IX and factor X by proteolysis and initiates the coagulation process.
In many thrombotic situations, Factor VIIa–AT complexes are higher in patients' plasmas:
The Asserachrom® VIIa-AT is an assay to perform Factor VIIa-Antithrombin complexes is also an indirect measurement test of Tissue Factor activation.
Thanks to an anti-human Factor VIIa monoclonal antibody, Asserachrom® VIIa-AT is a specific, reliable, quantitative and reproducible test.