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Combination Reagents Calibration plasmas-Quality controls

Cat. NR. Reagent Calibration plasma Quality controls

00658 STA-Stachrom Plasminogen STA-Unicalibrator - Cat. Nr. 00675 STA-System Control N+P - Cat. Nr. 00678

00659 STA-Stachrom Antiplasmin STA-Unicalibrator - Cat. Nr. 00675 STA-System Control N+P - Cat. Nr. 00678

FIBRINOLYSIS

FIBRINOLYSIS Fibrinolysis

TAFI - Plasminogen - Antiplasmin - tPA - PAI

Cat. NR. Product name Product description Pack.

00346

STA-Stachrom TAFI Chromogenic assay for the quantitative determination of the Thrombin Activatable Fibrinolysis Inhibitor (TAFI) activity Research Product

2 vials of TAFI activator 2 vials of substrate 4 vials of carboxypeptidase A 2 vials of TAFI calibrator 2 vials of TAFI control

80 tests

00616

Asserachrom TAFIa/TAFIai Quantitative determination of activated and/or inactivated TAFI by ELISA method Research Product

3 x 2 coated strips 3 vials of TMB 3 vials of anti-TAFIa/ TAFIai Peroxidase 3 vials of dilution buffer 3 vials of TAFIa/TAFIai calibrator 1vial of washing solution 3 vials of TAFIa/TAFIai control

3 x 32 tests

00658 STA-Stachrom PlasminogenChromogenic assay of plasminogen 6 vials of streptokinase 6 vials of substrate 6 x 3 mL

00659 STA-Stachrom AntiplasminChromogenic assay of antiplasmin 4 vials of plasmin 4 vials of solvent 4 vials of substrate 4 x 2 mL 4 x 6 mL

00948 Asserachrom tPA Quantitative determination of tissue Plasminogen Activator (tPA) by ELISA method

3 x 2 coated strips 3 vials of TMB 3 vials of anti-tPA peroxidase 3 vials of dilution buffer 3 vials of tPA calibrator 1 vial of washing solution 3 vials of tPA control

3 x 32 tests

00807 Stachrom PAI Chromogenic assay of Plasminogen Activator Inhibitor 1 (PAI 1)

2 vials of urokinase 2 vials of PAI calibrator 1 2 vials of plasminogen 2 vials of PAI calibrator 2 2 vials of substrate 2 vials of PAI calibrator 3

2 x 2 mL

00949 Asserachrom PAI 1 Quantitative determination of Plasminogen Activator Inhibitor 1 (PAI 1) by ELISA method

3 x 2 coated strips 3 vials of TMB 3 vials of anti-PAI 1 peroxidase 3 vials of dilution buffer 3 vials of PAI 1 calibrator 1 vial of washing solution 3 vials of PAI 1 control

3 x 32 tests

The specific degradation of fibrin (i.e., fibrinolysis) is the reactive mechanism responding to the formation of fibrin. Plasmin is the fibrinolytic enzyme derived from the inactive plasminogen. Plasminogen is converted into plasmin by plasminogen activators. The main plasminogen activators are the tissue Plasminogen Activator (tPA) and the pro-urokinase which is activated into urokinase (UK) by, among others, the contact system of coagulation. In the bloodstream, plasmin is rapidly and specifically neutralized by α2-antiplasmin thereby restricting its fibrinogenolytic activity and localising the fibrinolysis on the fibrin clot.

On the fibrin clot plasmin degrades fibrin into various products. Antibodies specific of these products, which do not recognize fibrinogen, have been developed. The presence of these various fibrin degradation products, among which D-dimer is the terminal product, is proof that the fibrinolytic system is in action in response to coagulation activation.

R EA

G EN

TS

55