Stago webinar: Bleeding disorders of unknown cause - challenges in diagnosis and patient management

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Bleeding disorder of unknown cause (BDUC) is a diagnosis of exclusion assigned to patients with a mild to moderate bleeding tendency who do not meet criteria for coagulation factor deficiencies, von Willebrand disease, or platelet function defects. 

Emerging data indicates that BDUC is more prevalent than previously assumed, accounting for nearly two-thirds of patients within the Vienna Bleeding Biobank. Individuals with BDUC often experience recurrent bleeding and remain at increased risk of hemorrhage in the context of invasive or surgical procedure. 

The high prevalence of this condition, together with its clinical impact, underscores the need to identify BDUC as a distinct bleeding disorder and to establish standardized management strategies.

The diagnostic of BDUC remains challenging. Affected individuals exhibit bleeding patterns and severities that are indistinguishable from those observed in well-defined mild bleeding disorders. 

Additional diagnostic difficulties arise from the limitations of current assays used to detect mild platelet function disorders and subtle forms of von Willebrand disease. 

The limited sensitivity and standardization of available assays as well as biological variability may contribute to underestimation of these conditions. Genomic and proteomic investigations have not identified a clear mechanism for BDUC, suggesting a multifactorial pathophysiology.

Stago webinars are developed and overseen by the Medical Affairs Department, under the scientific coordination of Dr. François Depasse, Dr. Joffrey Feriel and Dr. Marjorie Goujon. Our Medical Affairs team supports healthcare professionals in continuously advancing their practice and strengthening the scientific value of their projects.