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5B9 Monoclonal Antibody kits are available in stock to order

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5B9 is a monoclonal antibody that fully mimics the effects of human Heparin Induced Thrombocytopenia (HIT) antibodies [1]:

  • anti-PF4/Heparin IgG antibody with human Fc fragment,
  • induces heparin- and FcϒRIIA-dependent platelet activation,
  • specific to the PF4/Heparin complex with very low reactivity against PF4 alone.

5B9 clinical research on HIT functional assays covers the following objectives:

  • identification of “good” or “bad” platelet donors responders, [2]
  • evaluation of platelet reactivity, [2]
  • preparation of positive samples. [3]

5B9 may be also used as a specific tool when studying FcϒR-dependent cell activation in the pathophysiology of HIT. [1]

Kits are available in stock to order




The following table summarizes the minimal final 5B9 concentration in the sample for which each assay gives positive results:



1. KIZLIK-MASSON C., VAYNE C., MCKENZIE S.E., POUPON A., ZHOU Y., CHAMPIER G. POUPLARD C., GRUEL Y., ROLLIN J.: “5B9, a monoclonal antiplatelet factor 4/heparin IgG with a human Fc fragment that mimics heparin-induced thrombocytopenia antibodies”. J.Thromb. Haemost., 15, 2065-2075, 2017.

2. VAYNE C., GUERY E.A., CHARUEL N., BESOMBES J., LAMBERT W.C., ROLLIN J., GRUEL Y., POUPLARD C.: “Evaluation of functional assays for the diagnosis of heparin induced thrombocytopenia using 5B9, a monoclonal IgG that mimics human antibodies”. J. Thromb. Haemost., 18, 968-975, 2020.

3. Can 5B9, a monoclonal anti-PF4/heparin IgG, be used as an internal quality control for HIT platelet functional assays? Présentation Y Gruel SSC Platelet Immunology ISTH 2020.

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